Dr. Nousheen Zaidi
In 2008 Dr. Nousheen Zaidi received her doctoral degree in biochemistry from Eberhard Karls University, Tubingen, Germany. After completing her PhD training she moved to New York City and started her post-doctoral research at the Albert Einstein College of Medicine. There she worked from 2009 to 2010. In early 2011, Dr. Zaidi joined the Drug Discovery Group, Oncology, Johnson and Johnson (J&J), Belgium as a postdoctoral research associate. At J&J she worked on a project related to tumor metabolism. In late 2012, Dr. Zaidi moved to Lahore to join the faculty of the Department of Microbiology and Molecular Genetics, Punjab University. Her lab continues to focus on tumor metabolism that has emerged as one of the most exciting and dynamic fields of research for the academic and industrial scientists working in cancer therapeutics. Dr. Zaidi is mainly interested in studying the role of de novo lipid synthesis pathways in cancer cell development, progression and survival. To study the relative importance of dietary and endogenously synthesized lipids for cancer cell progression is one of the key aims of her ongoing/future projects. Currently, she is also a visiting scientist at Bundesanstalt für Materialforschung und -prüfung (BAM) (2017-2019) (Supported by Georg Forster Research Fellowship for Experienced Researchers by the Humboldt Foundation, 2017- 19).
- Ameer F, Munir R, and Zaidi N. Invited chapter in: Lipid Metabolism in Encyclopedia of Cancer 3rd Edition 2019.
- Zaidi N. and Kalbacher H. Cathepsin E, Invited chapter in: The Handbook of Proteolytic Enzymes 3rd Edition. 2012.
Journal Article Publications
- Munir R, Lisec J, Swinnen JV, Zaidi N: Lipid metabolism in cancer cells under metabolic stress. British journal of cancer 2019, 120(12):1090-1098.
- Lisec J, Jaeger C, Rashid R, Munir R, Zaidi N: Cancer cell lipid class homeostasis is altered under nutrient-deprivation but stable under hypoxia. BMC cancer 2019, 19(1):501.
- Zaid M, Ameer F, Munir R, Rashid R, Farooq N, Hasnain S, Zaidi N: Anthropometric and metabolic indices in assessment of type and severity of dyslipidemia. Journal of physiological anthropology 2017, 36(1):19.
- Ameer F, Munir R, Usman H, Rashid R, Shahjahan M, Hasnain S, Zaidi N: Lipid-load in peripheral blood mononuclear cells: Impact of food-consumption, dietary-macronutrients, extracellular lipid availability and demographic factors. Biochimie 2017, 135:104-110.
- Usman H, Ameer F, Munir R, Iqbal A, Zaid M, Hasnain S, Scandiuzzi L, Zaidi N: Leukemia cells display lower levels of intracellular cholesterol irrespective of the exogenous cholesterol availability. Clinica chimica acta; international journal of clinical chemistry 2016, 457:12-17.
- Iqbal A, Zaid M, Munir R, Usman H, Kalbacher H, Scandiuzzi L, Zaidi N: Atypical plasma lipid profiles in leukemia. Clinica chimica acta; international journal of clinical chemistry 2016, 452:129-133.
- Usman H, Rashid R, Ameer F, Iqbal A, Zaid M, Hasnain S, Kalbacher H, Zaidi N: Revisiting the dyslipidemia associated with acute leukemia. Clinica chimica acta; international journal of clinical chemistry 2015, 444:43-49.
- Rashid R, Ameer F, Kalbacher H, Scandiuzzi L, Zaidi N: Aberrant de novo cholesterogenesis: Clinical significance and implications. Clinica chimica acta; international journal of clinical chemistry 2015, 450:356-361.
- Daniels VW, Smans K, Royaux I, Chypre M, Swinnen JV, Zaidi N: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. PloS one 2014, 9(9):e106913.
- Munir R, Usman H, Hasnain S, Smans K, Kalbacher H, Zaidi N: Atypical plasma lipid profile in cancer patients: cause or consequence? Biochimie 2014, 102:9-18.
- Ameer F, Scandiuzzi L, Hasnain S, Kalbacher H, Zaidi N: De novo lipogenesis in health and disease. Metabolism: clinical and experimental 2014, 63(7):895-902.
- Zaidi N, Lupien L, Kuemmerle NB, Kinlaw WB, Swinnen JV, Smans K: Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Progress in lipid research 2013, 52(4):585-589.
- Zaidi N, Swinnen JV, Smans K: ATP-citrate lyase: a key player in cancer metabolism. Cancer research 2012, 72(15):3709-3714.
- Zaidi N, Royaux I, Swinnen JV, Smans K: ATP citrate lyase knockdown induces growth arrest and apoptosis through different cell- and environment-dependent mechanisms. Molecular cancer therapeutics 2012, 11(9):1925-1935.
- Chypre M, Zaidi N, Smans K: ATP-citrate lyase: a mini-review. Biochemical and biophysical research communications 2012, 422(1):1-4.
- Zaidi N, Maurer A, Nieke S, Kalbacher H: Cathepsin D: a cellular roadmap. Biochemical and biophysical research communications 2008, 376(1):5-9.
- Zaidi N, Hermann C, Herrmann T, Kalbacher H: Emerging functional roles of cathepsin E. Biochemical and biophysical research communications 2008, 377(2):327-330.
- Waraich RS, Zaidi N, Moeschel K, Beck A, Weigert C, Voelter W, Kalbacher H, Lehmann R: Development and precise characterization of phospho-site-specific antibody of Ser(357) of IRS-1: elimination of cross reactivity with adjacent Ser(358). Biochemical and biophysical research communications 2008, 376(1):26-31.
- Burster T, Reich M, Zaidi N, Voelter W, Boehm BO, Kalbacher H: Cathepsin E regulates the presentation of tetanus toxin C-fragment in PMA activated primary human B cells. Biochemical and biophysical research communications 2008, 377(4):1299-1303.
- Zaidi N, Kalbacher H: Cathepsin E: a mini review. Biochemical and biophysical research communications 2008, 367(3):517-522.
- Zaidi N, Herrmann T, Voelter W, Kalbacher H: Recombinant cathepsin E has no proteolytic activity at neutral pH. Biochemical and biophysical research communications 2007, 360(1):51-55.
- Zaidi N, Herrmann T, Baechle D, Schleicher S, Gogel J, Driessen C, Voelter W, Kalbacher H: A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles. The FEBS journal 2007, 274(12):3138-3149.
- Zaidi N, Burster T, Sommandas V, Herrmann T, Boehm BO, Driessen C, Voelter W, Kalbacher H: A novel cell penetrating aspartic protease inhibitor blocks processing and presentation of tetanus toxoid more efficiently than pepstatin A. Biochemical and biophysical research communications 2007, 364(2):243-249.
- Munir R, Lisec J, Jaeger C, Zaidi N: Abundance, fatty acid composition and saturation index of neutral lipids are significantly different between isogenic primary and metastatic colon cancer cell lines. 2019:690685.
- Zaid M, Ameer F, Ali A, Shoukat Z, Rashid R, Iqbal I, Zaidi N: Comparing the metabolic fates of BALB/c mice maintained on cafeteria-style diets with differential nutritive values. 2018:391821.